In silico Derivation of HLA-Specific Alloreactivity Potential from Whole Exome Sequencing of Stem-Cell Transplant Donors and Recipients: Understanding the Quantitative Immunobiology of Allogeneic Transplantation

Donor T-cell mediated graft versus host (GVH) effects may result from the aggregate alloreactivity to minor histocompatibility antigens (mHA) presented by the human leukocyte antigen (HLA) molecules in each donor–recipient pair undergoing stem-cell transplantation (SCT). Whole exome sequencing has p...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Jameson-Lee, Max, Koparde, Vishal, Griffith, Phil, Scalora, Allison F., Sampson, Juliana K., Khalid, Haniya, Sheth, Nihar U., Batalo, Michael, Serrano, Myrna G., Roberts, Catherine H., Hess, Michael L., Buck, Gregory A., Neale, Michael C., Manjili, Masoud H., Toor, Amir Ahmed
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2014
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4222229/
https://ncbi.nlm.nih.gov/pubmed/25414699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2014.00529
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