In silico Derivation of HLA-Specific Alloreactivity Potential from Whole Exome Sequencing of Stem-Cell Transplant Donors and Recipients: Understanding the Quantitative Immunobiology of Allogeneic Transplantation

Donor T-cell mediated graft versus host (GVH) effects may result from the aggregate alloreactivity to minor histocompatibility antigens (mHA) presented by the human leukocyte antigen (HLA) molecules in each donor–recipient pair undergoing stem-cell transplantation (SCT). Whole exome sequencing has p...

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Veröffentlicht in:Front Immunol
Hauptverfasser: Jameson-Lee, Max, Koparde, Vishal, Griffith, Phil, Scalora, Allison F., Sampson, Juliana K., Khalid, Haniya, Sheth, Nihar U., Batalo, Michael, Serrano, Myrna G., Roberts, Catherine H., Hess, Michael L., Buck, Gregory A., Neale, Michael C., Manjili, Masoud H., Toor, Amir Ahmed
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2014
Schlagworte:
Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4222229/
https://ncbi.nlm.nih.gov/pubmed/25414699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2014.00529
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