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Orienting the causal relationship between imprecisely measured traits using GWAS summary data

Inference about the causal structure that induces correlations between two traits can be achieved by combining genetic associations with a mediation-based approach, as is done in the causal inference test (CIT). However, we show that measurement error in the phenotypes can lead to the CIT inferring...

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書目詳細資料
發表在:PLoS Genet
Main Authors: Hemani, Gibran, Tilling, Kate, Davey Smith, George
格式: Artigo
語言:Inglês
出版: Public Library of Science 2017
主題:
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5711033/
https://ncbi.nlm.nih.gov/pubmed/29149188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007081
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