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Orienting the causal relationship between imprecisely measured traits using GWAS summary data

Inference about the causal structure that induces correlations between two traits can be achieved by combining genetic associations with a mediation-based approach, as is done in the causal inference test (CIT). However, we show that measurement error in the phenotypes can lead to the CIT inferring...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Hemani, Gibran, Tilling, Kate, Davey Smith, George
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5711033/
https://ncbi.nlm.nih.gov/pubmed/29149188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007081
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