A Pharmacologic Activator of Endothelial KCa Channels Increases Systemic Conductance and Reduces Arterial Pressure in an Anesthetized Pig Model

SKA-31, an activator of endothelial KCa2.3 and KCa3.1 channels, reduces systemic blood pressure in mice and dogs, however, its effects in larger mammals are not well known. We therefore examined the hemodynamic effects of SKA-31, along with sodium nitroprusside (SNP), in anesthetized, juvenile male...

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Publicat a:Vascul Pharmacol
Autors principals: Mishra, Ramesh, Mitchell, Jamie R., Gibbons-Kroeker, Carol, Wulff, Heike, Belenkie, Israel, Tyberg, John V., Braun, Andrew P.
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5710011/
https://ncbi.nlm.nih.gov/pubmed/26239885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vph.2015.07.016
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