Developmental YAPdeltaC determines adult pathology in a model of spinocerebellar ataxia type 1

YAP and its neuronal isoform YAPdeltaC are implicated in various cellular functions. We found that expression of YAPdeltaC during development, but not adulthood, rescued neurodegeneration phenotypes of mutant ataxin-1 knock-in (Atxn1-KI) mice. YAP/YAPdeltaC interacted with RORα via the second WW dom...

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Published in:Nat Commun
Main Authors: Fujita, Kyota, Mao, Ying, Uchida, Shigenori, Chen, Xigui, Shiwaku, Hiroki, Tamura, Takuya, Ito, Hikaru, Watase, Kei, Homma, Hidenori, Tagawa, Kazuhiko, Sudol, Marius, Okazawa, Hitoshi
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5709507/
https://ncbi.nlm.nih.gov/pubmed/29192206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01790-z
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