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Developmental YAPdeltaC determines adult pathology in a model of spinocerebellar ataxia type 1
YAP and its neuronal isoform YAPdeltaC are implicated in various cellular functions. We found that expression of YAPdeltaC during development, but not adulthood, rescued neurodegeneration phenotypes of mutant ataxin-1 knock-in (Atxn1-KI) mice. YAP/YAPdeltaC interacted with RORα via the second WW dom...
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| Publicat a: | Nat Commun |
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| Autors principals: | , , , , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group UK
2017
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5709507/ https://ncbi.nlm.nih.gov/pubmed/29192206 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01790-z |
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