Restoration of patterned vision with an engineered photoactivatable G protein-coupled receptor

Retinitis pigmentosa results in blindness due to degeneration of photoreceptors, but spares other retinal cells, leading to the hope that expression of light-activated signaling proteins in the surviving cells could restore vision. We used a retinal G protein-coupled receptor, mGluR2, which we chemi...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Commun
Prif Awduron: Berry, Michael H., Holt, Amy, Levitz, Joshua, Broichhagen, Johannes, Gaub, Benjamin M., Visel, Meike, Stanley, Cherise, Aghi, Krishan, Kim, Yang Joon, Cao, Kevin, Kramer, Richard H., Trauner, Dirk, Flannery, John, Isacoff, Ehud Y.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2017
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5709376/
https://ncbi.nlm.nih.gov/pubmed/29192252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01990-7
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