Restoration of patterned vision with an engineered photoactivatable G protein-coupled receptor

Retinitis pigmentosa results in blindness due to degeneration of photoreceptors, but spares other retinal cells, leading to the hope that expression of light-activated signaling proteins in the surviving cells could restore vision. We used a retinal G protein-coupled receptor, mGluR2, which we chemi...

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Pubblicato in:Nat Commun
Autori principali: Berry, Michael H., Holt, Amy, Levitz, Joshua, Broichhagen, Johannes, Gaub, Benjamin M., Visel, Meike, Stanley, Cherise, Aghi, Krishan, Kim, Yang Joon, Cao, Kevin, Kramer, Richard H., Trauner, Dirk, Flannery, John, Isacoff, Ehud Y.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5709376/
https://ncbi.nlm.nih.gov/pubmed/29192252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01990-7
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