Restoration of patterned vision with an engineered photoactivatable G protein-coupled receptor

Retinitis pigmentosa results in blindness due to degeneration of photoreceptors, but spares other retinal cells, leading to the hope that expression of light-activated signaling proteins in the surviving cells could restore vision. We used a retinal G protein-coupled receptor, mGluR2, which we chemi...

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Detaylı Bibliyografya
Yayımlandı:Nat Commun
Asıl Yazarlar: Berry, Michael H., Holt, Amy, Levitz, Joshua, Broichhagen, Johannes, Gaub, Benjamin M., Visel, Meike, Stanley, Cherise, Aghi, Krishan, Kim, Yang Joon, Cao, Kevin, Kramer, Richard H., Trauner, Dirk, Flannery, John, Isacoff, Ehud Y.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group UK 2017
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5709376/
https://ncbi.nlm.nih.gov/pubmed/29192252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01990-7
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