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A network diffusion approach to inferring sample-specific function reveals functional changes associated with breast cancer

Guilt-by-association codifies the empirical observation that a gene’s function is informed by its neighborhood in a biological network. This would imply that when a gene’s network context is altered, for instance in disease condition, so could be the gene’s function. Although context-specific change...

Полное описание

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Библиографические подробности
Опубликовано в: :PLoS Comput Biol
Главные авторы: Patkar, Sushant, Magen, Assaf, Sharan, Roded, Hannenhalli, Sridhar
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2017
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5708603/
https://ncbi.nlm.nih.gov/pubmed/29190299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1005793
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