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A network diffusion approach to inferring sample-specific function reveals functional changes associated with breast cancer

Guilt-by-association codifies the empirical observation that a gene’s function is informed by its neighborhood in a biological network. This would imply that when a gene’s network context is altered, for instance in disease condition, so could be the gene’s function. Although context-specific change...

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Veröffentlicht in:PLoS Comput Biol
Hauptverfasser: Patkar, Sushant, Magen, Assaf, Sharan, Roded, Hannenhalli, Sridhar
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2017
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5708603/
https://ncbi.nlm.nih.gov/pubmed/29190299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1005793
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