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Desensitization and Tolerance of Mu Opioid Receptors on Pontine Kölliker-Fuse Neurons

Acute desensitization of mu opioid receptors is thought to be an initial step in the development of tolerance to opioids. Given the resistance of the respiratory system to develop tolerance, desensitization of neurons in the Kölliker-Fuse (KF), a key area in the respiratory circuit, was examined. Th...

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Bibliographic Details
Published in:Mol Pharmacol
Main Authors: Levitt, Erica S., Williams, John T.
Format: Artigo
Language:Inglês
Published: The American Society for Pharmacology and Experimental Therapeutics 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5708089/
https://ncbi.nlm.nih.gov/pubmed/29097440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.117.109603
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