Cross-reactivity of antibodies against interferon beta in multiple sclerosis patients and interference of the JAK-STAT signaling pathway

Interferon beta (IFNβ) therapy has immunogenic properties and induces the development of neutralizing antibodies (NAbs). From the extensive literature focused in the development of NAbs in multiple sclerosis (MS) patients, their ability to cross-react has been deficiently evaluated, despite having i...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Hurtado-Guerrero, Isaac, Pinto-Medel, Maria Jesus, Urbaneja, Patricia, Rodriguez-Bada, Jose Luis, Ortega-Pinazo, Jesús, Serrano, Pedro, Fernández, Óscar, Leyva, Laura, Oliver-Martos, Begoña
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5707350/
https://ncbi.nlm.nih.gov/pubmed/29185487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-16828-x
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