Global methylation correlates with clinical status in multiple sclerosis patients in the first year of IFNbeta treatment

The alteration of DNA methylation patterns are a key component of disease onset and/or progression. Our objective was to evaluate the differences in Long Interspersed Nuclear Element-1 (LINE-1) methylation levels, as a surrogate marker of global DNA methylation, between multiple sclerosis (MS) patie...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Pinto-Medel, María Jesús, Oliver-Martos, Begoña, Urbaneja-Romero, Patricia, Hurtado-Guerrero, Isaac, Ortega-Pinazo, Jesús, Serrano-Castro, Pedro, Fernández, Óscar, Leyva, Laura
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5562733/
https://ncbi.nlm.nih.gov/pubmed/28821874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-09301-2
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