Enhancer remodeling regulates epigenetic adaptation and resistance to MEK1/2 inhibition in triple-negative breast cancer

Kinase inhibitors targeting the mitogen/extracellular signal-regulated kinase kinase (MEK)- extracellular signal related kinase (ERK) signaling pathway have limited durability in inhibiting growth of triple-negative breast cancer. We defined genome wide enhancer remodeling following MEK inhibition c...

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Pubblicato in:Mol Cell Oncol
Autori principali: Bevill, Samantha M., Zawistowski, Jon S., Johnson, Gary L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5706954/
https://ncbi.nlm.nih.gov/pubmed/29209639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23723556.2017.1300622
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