Targeting RAS – will GPR31 deliver us a new path forward?

Effective anti-rat sarcoma viral oncogene (RAS) therapies have remained the holy grail of cancer treatment. Mutant Kirsten rat sarcoma viral oncogene homolog (KRAS) sustains tumorigenesis when linked to the plasma membrane (PM). The G protein-coupled receptor 31 (GPR31) is now identified to mediate...

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Bibliographic Details
Published in:Mol Cell Oncol
Main Authors: Fehrenbacher, Nicole, Philips, Mark R.
Format: Artigo
Language:Inglês
Published: Taylor & Francis 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5706936/
https://ncbi.nlm.nih.gov/pubmed/29209647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23723556.2017.1359228
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