Histone deacetylase inhibitors reduce differentiating osteoblast-mediated protection of acute myeloid leukemia cells from cytarabine

The bone marrow microenvironment protects acute myeloid leukemia (AML) cells during chemotherapy and is a major factor in relapse. Here, we examined which type(s) of bone marrow cells are responsible for the relapse of AML following treatment with cytarabine (Ara-C), and we identified a means to inh...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Sterner, Rosalie M., Kremer, Kimberly N., Al-Kali, Aref, Patnaik, Mrinal M., Gangat, Naseema, Litzow, Mark R., Kaufmann, Scott H., Westendorf, Jennifer J., van Wijnen, Andre J., Hedin, Karen E.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5706896/
https://ncbi.nlm.nih.gov/pubmed/29212250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.21809
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