Nimbolide reduces CD44 positive cell population and induces mitochondrial apoptosis in pancreatic cancer cells

Pancreatic ductal adenocarcinoma (PDAC) is highly aggressive disease and current treatment regimens fail to effectively cure PDAC. Development of resistance to current therapy is one of the key reasons for this outcome. Nimbolide (NL), a triterpenoid obtained from Azadirachta indica, exhibits antica...

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Foilsithe in:Cancer Lett
Main Authors: Kumar, Sandeep, Inigo, Joseph R., Kumar, Rahul, Chaudhary, Ajay K., O’Malley, Jordan, Balachandar, Srimmitha, Wang, Jianmin, Attwood, Kristopher, Yadav, Neelu, Hochwald, Steven, Wang, Xinjiang, Chandra, Dhyan
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2017
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5706561/
https://ncbi.nlm.nih.gov/pubmed/29107110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2017.10.029
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