UTX/KDM6A Loss Enhances the Malignant Phenotype of Multiple Myeloma and Sensitizes Cells to EZH2 inhibition

Loss or inactivation of the histone H3K27 demethylase UTX occurs in several malignancies, including multiple myeloma (MM). Using an isogenic cell system, we found that loss of UTX leads to deactivation of gene expression ultimately promoting the proliferation, clonogenicity, adhesion and tumorigenic...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Ezponda, Teresa, Dupéré-Richer, Daphné, Will, Christine M., Small, Eliza C., Varghese, Nobish, Patel, Tej, Nabet, Behnam, Popovic, Relja, Oyer, Jon, Bulic, Marinka, Zheng, Yupeng, Huang, Xiaoxiao, Shah, Mrinal Y., Maji, Sayantan, Riva, Alberto, Occhionorelli, Manuela, Tonon, Giovanni, Kelleher, Neil, Keats, Jonathan, Licht, Jonathan D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5706555/
https://ncbi.nlm.nih.gov/pubmed/29045832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.09.078
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