MDM2 is implicated in high‐glucose‐induced podocyte mitotic catastrophe via Notch1 signalling

Podocyte injury and depletion are essential events involved in the pathogenesis of diabetic nephropathy (DN). As a terminally differentiated cell, podocyte is restricted in ‘post‐mitosis’ state and unable to regenerate. Re‐entering mitotic phase will cause podocyte disastrous death which is defined...

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Detalhes bibliográficos
Publicado no:J Cell Mol Med
Main Authors: Tang, Hui, Lei, Chun‐Tao, Ye, Chen, Gao, Pan, Wan, Cheng, Chen, Shan, He, Fang‐Fang, Wang, Yu‐Mei, Su, Hua, Zhang, Chun
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5706520/
https://ncbi.nlm.nih.gov/pubmed/28643424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.13253
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