NADPH Oxidase-Induced NALP3 Inflammasome Activation Is Driven by Thioredoxin-Interacting Protein Which Contributes to Podocyte Injury in Hyperglycemia

Diabetic nephropathy (DN) is one of the major causes of end-stage renal disease, and previously we demonstrated that NALP3 inflammasome was involved in the pathogenesis of DN. Here we investigated the mechanisms of NALP3 inflammasome activation in podocyte injury during DN. We found that, besides th...

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Veröffentlicht in:J Diabetes Res
Hauptverfasser: Gao, Pan, He, Fang-Fang, Tang, Hui, Lei, Chun-Tao, Chen, Shan, Meng, Xian-Fang, Su, Hua, Zhang, Chun
Format: Artigo
Sprache:Inglês
Veröffentlicht: Hindawi Publishing Corporation 2015
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4365330/
https://ncbi.nlm.nih.gov/pubmed/25834832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2015/504761
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