MDM2 Contributes to High Glucose-Induced Glomerular Mesangial Cell Proliferation and Extracellular Matrix Accumulation via Notch1

Murine double minute 2 (MDM2) is an E3-ubiquitin ligase critical for various biological functions. Previous data have revealed an indispensable role of MDM2 in kidney homeostasis. However, its role in glomerular mesangial cell (GMC) proliferation and extracellular matrix (ECM) accumulation during hy...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Lei, Chun-Tao, Tang, Hui, Ye, Chen, You, Chao-Qun, Zhang, Jiao, Zhang, Chun-Yun, Xiong, Wei, Su, Hua, Zhang, Chun
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5583188/
https://ncbi.nlm.nih.gov/pubmed/28871126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-10927-5
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