Linkage, whole genome sequence, and biological data implicate variants in RAB10 in Alzheimer’s disease resilience

BACKGROUND: While age and the APOE ε4 allele are major risk factors for Alzheimer’s disease (AD), a small percentage of individuals with these risk factors exhibit AD resilience by living well beyond 75 years of age without any clinical symptoms of cognitive decline. METHODS: We used over 200 “AD re...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Genome Med
Main Authors: Ridge, Perry G., Karch, Celeste M., Hsu, Simon, Arano, Ivan, Teerlink, Craig C., Ebbert, Mark T. W., Gonzalez Murcia, Josue D., Farnham, James M., Damato, Anna R., Allen, Mariet, Wang, Xue, Harari, Oscar, Fernandez, Victoria M., Guerreiro, Rita, Bras, Jose, Hardy, John, Munger, Ronald, Norton, Maria, Sassi, Celeste, Singleton, Andrew, Younkin, Steven G., Dickson, Dennis W., Golde, Todd E., Price, Nathan D., Ertekin-Taner, Nilüfer, Cruchaga, Carlos, Goate, Alison M., Corcoran, Christopher, Tschanz, JoAnn, Cannon-Albright, Lisa A., Kauwe, John S. K.
פורמט: Artigo
שפה:Inglês
יצא לאור: BioMed Central 2017
נושאים:
Research
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC5706401/
https://ncbi.nlm.nih.gov/pubmed/29183403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13073-017-0486-1
תגים: הוספת תג
אין תגיות, היה/י הראשונ/ה לתייג את הרשומה!

פריטים דומים