Linkage, whole genome sequence, and biological data implicate variants in RAB10 in Alzheimer’s disease resilience

BACKGROUND: While age and the APOE ε4 allele are major risk factors for Alzheimer’s disease (AD), a small percentage of individuals with these risk factors exhibit AD resilience by living well beyond 75 years of age without any clinical symptoms of cognitive decline. METHODS: We used over 200 “AD re...

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Enregistré dans:
Détails bibliographiques
Publié dans:Genome Med
Auteurs principaux: Ridge, Perry G., Karch, Celeste M., Hsu, Simon, Arano, Ivan, Teerlink, Craig C., Ebbert, Mark T. W., Gonzalez Murcia, Josue D., Farnham, James M., Damato, Anna R., Allen, Mariet, Wang, Xue, Harari, Oscar, Fernandez, Victoria M., Guerreiro, Rita, Bras, Jose, Hardy, John, Munger, Ronald, Norton, Maria, Sassi, Celeste, Singleton, Andrew, Younkin, Steven G., Dickson, Dennis W., Golde, Todd E., Price, Nathan D., Ertekin-Taner, Nilüfer, Cruchaga, Carlos, Goate, Alison M., Corcoran, Christopher, Tschanz, JoAnn, Cannon-Albright, Lisa A., Kauwe, John S. K.
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2017
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5706401/
https://ncbi.nlm.nih.gov/pubmed/29183403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13073-017-0486-1
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