Linkage, whole genome sequence, and biological data implicate variants in RAB10 in Alzheimer’s disease resilience

BACKGROUND: While age and the APOE ε4 allele are major risk factors for Alzheimer’s disease (AD), a small percentage of individuals with these risk factors exhibit AD resilience by living well beyond 75 years of age without any clinical symptoms of cognitive decline. METHODS: We used over 200 “AD re...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Genome Med
Prif Awduron: Ridge, Perry G., Karch, Celeste M., Hsu, Simon, Arano, Ivan, Teerlink, Craig C., Ebbert, Mark T. W., Gonzalez Murcia, Josue D., Farnham, James M., Damato, Anna R., Allen, Mariet, Wang, Xue, Harari, Oscar, Fernandez, Victoria M., Guerreiro, Rita, Bras, Jose, Hardy, John, Munger, Ronald, Norton, Maria, Sassi, Celeste, Singleton, Andrew, Younkin, Steven G., Dickson, Dennis W., Golde, Todd E., Price, Nathan D., Ertekin-Taner, Nilüfer, Cruchaga, Carlos, Goate, Alison M., Corcoran, Christopher, Tschanz, JoAnn, Cannon-Albright, Lisa A., Kauwe, John S. K.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: BioMed Central 2017
Pynciau:
Research
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5706401/
https://ncbi.nlm.nih.gov/pubmed/29183403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13073-017-0486-1
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg