Deficiency of the Purinergic Receptor 2X(7) Attenuates Nonalcoholic Steatohepatitis Induced by High-Fat Diet: Possible Role of the NLRP3 Inflammasome

Molecular mechanisms driving transition from simple steatosis to nonalcoholic steatohepatitis (NASH), a critical step in the progression of nonalcoholic fatty liver disease (NAFLD) to cirrhosis, are poorly defined. This study aimed at investigating the role of the purinergic receptor 2X(7) (PR2X(7))...

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Veröffentlicht in:Oxid Med Cell Longev
Hauptverfasser: Blasetti Fantauzzi, Claudia, Menini, Stefano, Iacobini, Carla, Rossi, Chiara, Santini, Eleonora, Solini, Anna, Pugliese, Giuseppe
Format: Artigo
Sprache:Inglês
Veröffentlicht: Hindawi 2017
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5705892/
https://ncbi.nlm.nih.gov/pubmed/29270247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2017/8962458
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