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Insights into immune tolerance from AIRE deficiency
AIRE is a well-established master regulator of central tolerance. It plays an essential role in driving expression of tissue-specific antigens in the thymus and shaping the development of positively selected T-cells. Humans and mice with compromised or absent AIRE function have markedly variable phe...
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| Veröffentlicht in: | Curr Opin Immunol |
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| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5705335/ https://ncbi.nlm.nih.gov/pubmed/29065385 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.coi.2017.10.003 |
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