Identification of a novel cis-regulatory element essential for immune tolerance

Thymic central tolerance is essential to preventing autoimmunity. In medullary thymic epithelial cells (mTECs), the Autoimmune regulator (Aire) gene plays an essential role in this process by driving the expression of a diverse set of tissue-specific antigens (TSAs), which are presented and help tol...

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Bibliografske podrobnosti
izdano v:J Exp Med
Main Authors: LaFlam, Taylor N., Seumois, Grégory, Miller, Corey N., Lwin, Wint, Fasano, Kayla J., Waterfield, Michael, Proekt, Irina, Vijayanand, Pandurangan, Anderson, Mark S.
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 2015
Teme:
Research Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4647269/
https://ncbi.nlm.nih.gov/pubmed/26527800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20151069
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