Identification of a novel cis-regulatory element essential for immune tolerance

Thymic central tolerance is essential to preventing autoimmunity. In medullary thymic epithelial cells (mTECs), the Autoimmune regulator (Aire) gene plays an essential role in this process by driving the expression of a diverse set of tissue-specific antigens (TSAs), which are presented and help tol...

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Bibliografische gegevens
Gepubliceerd in:J Exp Med
Hoofdauteurs: LaFlam, Taylor N., Seumois, Grégory, Miller, Corey N., Lwin, Wint, Fasano, Kayla J., Waterfield, Michael, Proekt, Irina, Vijayanand, Pandurangan, Anderson, Mark S.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The Rockefeller University Press 2015
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Research Articles
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4647269/
https://ncbi.nlm.nih.gov/pubmed/26527800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20151069
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