Gastrin Induces Nuclear Export and Proteasomal Degradation of Menin in Enteric Glial Cells

BACKGROUND: The Multiple Endocrine Neoplasia, type 1 (MEN1) locus encodes the nuclear tumor suppressor protein menin. MEN1 mutations frequently cause neuroendocrine tumors (NETs) such as gastrinomas, remarkable for their predominant duodenal location and local metastasis at the time of diagnosis. Di...

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Publicado no:Gastroenterology
Main Authors: Sundaresan, Sinju, Meininger, Cameron A, Kang, Anthony J, Photenhauer, Amanda L, Hayes, Michael M, Sahoo, Nirakar, Grembecka, Jolanta, Cierpicki, Tomasz, Ding, Lin, Giordano, Thomas J., Else, Tobias, Madrigal, David J., Low, Malcolm J, Campbell, Fiona, Baker, Ann-Marie, Xu, Haoxing, Wright, Nicholas A, Merchant, Juanita L
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5705278/
https://ncbi.nlm.nih.gov/pubmed/28859856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2017.08.038
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