Immunoproteasome functions explained by divergence in cleavage specificity and regulation

The immunoproteasome (iP) has been proposed to perform specialized roles in MHC class I antigen presentation, cytokine modulation, and T cell differentiation and has emerged as a promising therapeutic target for autoimmune disorders and cancer. However, divergence in function between the iP and the...

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Veröffentlicht in:eLife
Hauptverfasser: Winter, Michael B, La Greca, Florencia, Arastu-Kapur, Shirin, Caiazza, Francesco, Cimermancic, Peter, Buchholz, Tonia J, Anderl, Janet L, Ravalin, Matthew, Bohn, Markus F, Sali, Andrej, O'Donoghue, Anthony J, Craik, Charles S
Format: Artigo
Sprache:Inglês
Veröffentlicht: eLife Sciences Publications, Ltd 2017
Schlagworte:
Biochemistry and Chemical Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5705213/
https://ncbi.nlm.nih.gov/pubmed/29182146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.27364
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