The eukaryotic translation initiation factor eIF4E harnesses hyaluronan production to drive its malignant activity

The microenvironment provides a functional substratum supporting tumour growth. Hyaluronan (HA) is a major component of this structure. While the role of HA in malignancy is well-defined, the mechanisms driving its biosynthesis in cancer are poorly understood. We show that the eukaryotic translation...

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Udgivet i:eLife
Main Authors: Zahreddine, Hiba Ahmad, Culjkovic-Kraljacic, Biljana, Emond, Audrey, Pettersson, Filippa, Midura, Ronald, Lauer, Mark, Del Rincon, Sonia, Cali, Valbona, Assouline, Sarit, Miller, Wilson H, Hascall, Vincent, Borden, Katherine LB
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2017
Fag:
Cancer Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5705209/
https://ncbi.nlm.nih.gov/pubmed/29111978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.29830
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