Cyclin D1 restrains oncogene-induced autophagy by regulating the AMPK-LKB1 signaling axis

Autophagy activated after DNA damage or other stresses mitigates cellular damage by removing damaged proteins, lipids and organelles. Activation of the master metabolic kinase AMPK enhances autophagy. Here we report that cyclin D1 restrains autophagy by modulating the activation of AMPK. In cell mod...

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Bibliografiska uppgifter
I publikationen:Cancer Res
Huvudupphovsmän: Casimiro, Mathew C., Di Sante, Gabriele, Di Rocco, Agnese, Loro, Emanuele, Pupo, Claudia, Pestell, Timothy G., Bisetto, Sara, Velasco-Velázquez, Marco A., Jiao, Xuanmao, Li, Zhiping, Kusminski, Christine M., Seifert, Erin L., Wang, Chenguang, Ly, Daniel, Zheng, Bin, Shen, Che-Hung, Scherer, Philipp E., Pestell, Richard G.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2017
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5705201/
https://ncbi.nlm.nih.gov/pubmed/28522753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-16-0425
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