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Substrate and Transition State Binding in Alkaline Phosphatase Analyzed by Computation of Oxygen Isotope Effects

Enzymes are powerful catalysts and a thorough understanding of the sources of their catalytic power will facilitate many medical and industrial applications. Here we have studied the catalytic mechanism of alkaline phosphatase (AP), which is one of the most catalytically proficient enzymes known. We...

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Publicado en:J Am Chem Soc
Main Authors: Roston, Daniel, Cui, Qiang
Formato: Artigo
Idioma:Inglês
Publicado: 2016
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5705178/
https://ncbi.nlm.nih.gov/pubmed/27541005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.6b07347
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