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Substrate and Transition State Binding in Alkaline Phosphatase Analyzed by Computation of Oxygen Isotope Effects
Enzymes are powerful catalysts and a thorough understanding of the sources of their catalytic power will facilitate many medical and industrial applications. Here we have studied the catalytic mechanism of alkaline phosphatase (AP), which is one of the most catalytically proficient enzymes known. We...
Enregistré dans:
| Publié dans: | J Am Chem Soc |
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| Auteurs principaux: | , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2016
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5705178/ https://ncbi.nlm.nih.gov/pubmed/27541005 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.6b07347 |
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