Cisplatin or LA-12 enhance killing effects of TRAIL in prostate cancer cells through Bid-dependent stimulation of mitochondrial apoptotic pathway but not caspase-10

Searching for new strategies for effective elimination of human prostate cancer cells, we investigated the cooperative cytotoxic action of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and two platinum-based complexes, cisplatin or LA-12, and related molecular mechanisms. We demons...

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Udgivet i:PLoS One
Main Authors: Vondálová Blanářová, Olga, Šafaříková, Barbora, Herůdková, Jarmila, Krkoška, Martin, Tománková, Silvie, Kahounová, Zuzana, Anděra, Ladislav, Bouchal, Jan, Kharaishvili, Gvantsa, Král, Milan, Sova, Petr, Kozubík, Alois, Hyršlová Vaculová, Alena
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5705153/
https://ncbi.nlm.nih.gov/pubmed/29182622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0188584
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