Translational strategies exploiting TNF-α that sensitize tumors to radiation therapy

TNFerade is a radioinducible adenoviral vector expressing tumor necrosis factor-α (TNF-α) (Ad.Egr-TNF) currently in a phase III trial for inoperable pancreatic cancer. We studied B16-F1 melanoma tumors in TNF receptor wild-type (C57BL/6) and deficient (TNFR1,2−/− and TNFR1−/−) mice. Ad.Egr-TNF+IR in...

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Detalhes bibliográficos
Publicado no:Cancer Gene Ther
Main Authors: Mauceri, HJ, Beckett, MA, Liang, H, Sutton, HG, Pitroda, S, Galka, E, Efimova, E, Darga, T, Khodarev, NN, King, CR, Posner, MC, Hellman, S, Kufe, DW, Weichselbaum, RR
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5705082/
https://ncbi.nlm.nih.gov/pubmed/18974777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cgt.2008.86
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