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Translational strategies exploiting TNF-α that sensitize tumors to radiation therapy
TNFerade is a radioinducible adenoviral vector expressing tumor necrosis factor-α (TNF-α) (Ad.Egr-TNF) currently in a phase III trial for inoperable pancreatic cancer. We studied B16-F1 melanoma tumors in TNF receptor wild-type (C57BL/6) and deficient (TNFR1,2−/− and TNFR1−/−) mice. Ad.Egr-TNF+IR in...
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| Publicado no: | Cancer Gene Ther |
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| Main Authors: | , , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5705082/ https://ncbi.nlm.nih.gov/pubmed/18974777 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cgt.2008.86 |
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