Ad.Egr-TNF and Local Ionizing Radiation Suppress Metastases by Interferon-β-Dependent Activation of Antigen-specific CD8(+) T Cells

Ad.Egr-TNF is a radioinducible adenovector currently in phase 3 trials for inoperable pancreatic cancer. The combination of Ad.Egr-TNF and ionizing radiation (IR) contributes to local tumor control through the production of tumor necrosis factor-α (TNFα) in the tumor microenvironment. Moreover, clin...

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Hlavní autoři: Meng, Yuru, Mauceri, Helena J, Khodarev, Nikolai N, Darga, Thomas E, Pitroda, Sean P, Beckett, Michael A, Kufe, Donald W, Weichselbaum, Ralph R
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2010
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Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2890103/
https://ncbi.nlm.nih.gov/pubmed/20197756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2010.18
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