α-Actinin Promotes Surface Localization and Current Density of the Ca(2+) Channel Ca(V)1.2 by Binding to the IQ Region of the α1 Subunit

The voltage-gated L-type Ca(2+) channel Ca(V)1.2 is crucial for initiating heartbeat and control of a number of neuronal functions such as neuronal excitability and long-term potentiation. Mutations of Ca(V)1.2 subunits result in serious health problems including arrhythmia, autism spectrum disorder...

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Publicado no:Biochemistry
Main Authors: Tseng, Pang-Yen, Henderson, Peter B., Hergarden, Anne C., Patriarchi, Tommaso, Coleman, Andrea, Lillya, Mark W., Montagut-Bordas, Carlota, Lee, Boram, Hell, Johannes W., Horne, Mary C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5704914/
https://ncbi.nlm.nih.gov/pubmed/28613835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.7b00359
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