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Mutagenic potential of nitrogen mustard-induced formamidopyrimidine DNA adduct: Contribution of the non-canonical α-anomer

Nitrogen mustards (NMs) are DNA-alkylating compounds that represent the earliest anticancer drugs. However, clinical use of NMs is limited because of their own mutagenic properties. The mechanisms of NM-induced mutagenesis remain unclear. The major product of DNA alkylation by NMs is a cationic NM-N...

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Dades bibliogràfiques
Publicat a:J Biol Chem
Autors principals: Minko, Irina G., Rizzo, Carmelo J., Lloyd, R. Stephen
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2017
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5704464/
https://ncbi.nlm.nih.gov/pubmed/28972137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.802520
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