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Role of the N-acetylation polymorphism in solithromycin metabolism

AIM: Solithromycin is a new macrolide antibiotic for the potential treatment of bacterial pneumonia. MATERIALS & METHODS: Solithromycin N-acetylation by human NAT1 and NAT2 was investigated following recombinant expression in yeast and in cryopreserved human hepatocytes from rapid, intermediate...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Pharmacogenomics
Prif Awduron: Hein, David W, Doll, Mark A
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Future Medicine Ltd 2017
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5704091/
https://ncbi.nlm.nih.gov/pubmed/28625123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2217/pgs-2017-0045
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