A Small Molecule Inhibitor of the β-Catenin-TCF4 Interaction Suppresses Colorectal Cancer Growth In Vitro and In Vivo

Colorectal cancer is associated with aberrant activation of the Wnt pathway. β-Catenin plays essential roles in the Wnt pathway by interacting with T-cell factor 4 (TCF4) to transcribe oncogenes. We synthesized a small molecule, referred to as HI-B1, and evaluated signaling changes and biological co...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Shin, Seung Ho, Lim, Do Young, Reddy, Kanamata, Malakhova, Margarita, Liu, Fangfang, Wang, Ting, Song, Mengqiu, Chen, Hanyong, Bae, Ki Beom, Ryu, Joohyun, Liu, Kangdong, Lee, Mee-Hyun, Bode, Ann M., Dong, Zigang
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5704052/
https://ncbi.nlm.nih.gov/pubmed/29033371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2017.09.029
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados