A natural small molecule, catechol, induces c-Myc degradation by directly targeting ERK2 in lung cancer

Various carcinogens induce EGFR/RAS/MAPK signaling, which is critical in the development of lung cancer. In particular, constitutive activation of extracellular signal-regulated kinase 2 (ERK2) is observed in many lung cancer patients, and therefore developing compounds capable of targeting ERK2 in...

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Publicado en:Oncotarget
Autores principales: Lim, Do Young, Shin, Seung Ho, Lee, Mee-Hyun, Malakhova, Margarita, Kurinov, Igor, Wu, Qiong, Xu, Jinglong, Jiang, Yanan, Dong, Ziming, Liu, Kangdong, Lee, Kun Yeong, Bae, Ki Beom, Choi, Bu Young, Deng, Yibin, Bode, Ann, Dong, Zigang
Formato: Artigo
Lenguaje:Inglês
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5085205/
https://ncbi.nlm.nih.gov/pubmed/27167001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.9223
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