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Autophagy enhancement is rendered ineffective in presence of α-synuclein in melanoma cells
Increased cellular concentration of α-synuclein (α-syn) predisposes it to misfolding and aggregation that in turn impair the degradation pathways. This poses a limitation to the use of overexpression models for studies on α-syn clearance by autophagy, which is widely investigated for its therapeutic...
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| Publicado no: | J Cell Commun Signal |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Springer Netherlands
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5704043/ https://ncbi.nlm.nih.gov/pubmed/28748508 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12079-017-0402-x |
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