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Combined inhibition of MEK and nuclear ERK translocation has synergistic antitumor activity in melanoma cells
Genetic alterations in BRAF, NRAS and NF1 that activate the ERK cascade, account for over 80% of metastatic melanomas. However, ERK cascade inhibitors have been proven beneficial almost exclusively for BRAF mutant melanomas. One of the hallmarks of the ERK cascade is the nuclear translocation of ERK...
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| Publicado no: | Sci Rep |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5704016/ https://ncbi.nlm.nih.gov/pubmed/29180761 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-16558-0 |
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