Nuclear ERK: Mechanism of Translocation, Substrates, and Role in Cancer

The extracellular signal-regulated kinases 1/2 (ERK) are central signaling components that regulate stimulated cellular processes such as proliferation and differentiation. When dysregulated, these kinases participate in the induction and maintenance of various pathologies, primarily cancer. While E...

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Detaylı Bibliyografya
Asıl Yazarlar: Galia Maik-Rachline, Avital Hacohen-Lev-Ran, Rony Seger
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: MDPI AG 2019-03-01
Seri Bilgileri:International Journal of Molecular Sciences
Konular:
mitogen-activated protein kinase (MAPK)
Beta-like importins
nuclear translocation
nuclear substrates
negative feedback loop
Online Erişim:http://www.mdpi.com/1422-0067/20/5/1194
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