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Combined inhibition of MEK and nuclear ERK translocation has synergistic antitumor activity in melanoma cells
Genetic alterations in BRAF, NRAS and NF1 that activate the ERK cascade, account for over 80% of metastatic melanomas. However, ERK cascade inhibitors have been proven beneficial almost exclusively for BRAF mutant melanomas. One of the hallmarks of the ERK cascade is the nuclear translocation of ERK...
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| 出版年: | Sci Rep |
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| 主要な著者: | , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group UK
2017
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5704016/ https://ncbi.nlm.nih.gov/pubmed/29180761 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-16558-0 |
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