Discovery of High-Affinity PDGF-VEGFR Interactions: Redefining RTK Dynamics

Nearly all studies of angiogenesis have focused on uni-family ligand-receptor binding, e.g., VEGFs bind to VEGF receptors, PDGFs bind to PDGF receptors, etc. The discovery of VEGF-PDGFRs binding challenges this paradigm and calls for investigation of other ligand-receptor binding possibilities. We u...

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Foilsithe in:Sci Rep
Main Authors: Mamer, Spencer B., Chen, Si, Weddell, Jared C., Palasz, Alexandra, Wittenkeller, Ashley, Kumar, Manu, Imoukhuede, P. I.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group UK 2017
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5704011/
https://ncbi.nlm.nih.gov/pubmed/29180757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-16610-z
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