Linear combinations of docking affinities explain quantitative differences in RTK signaling

Receptor tyrosine kinases (RTKs) process extracellular cues by activating a broad array of signaling proteins. Paradoxically, they often use the same proteins to elicit diverse and even opposing phenotypic responses. Binary, ‘on–off' wiring diagrams are therefore inadequate to explain their dif...

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Main Authors: Gordus, Andrew, Krall, Jordan A, Beyer, Elsa M, Kaushansky, Alexis, Wolf-Yadlin, Alejandro, Sevecka, Mark, Chang, Bryan H, Rush, John, MacBeath, Gavin
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2009
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2644171/
https://ncbi.nlm.nih.gov/pubmed/19156127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/msb.2008.72
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