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Linear combinations of docking affinities explain quantitative differences in RTK signaling
Receptor tyrosine kinases (RTKs) process extracellular cues by activating a broad array of signaling proteins. Paradoxically, they often use the same proteins to elicit diverse and even opposing phenotypic responses. Binary, ‘on–off' wiring diagrams are therefore inadequate to explain their dif...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2644171/ https://ncbi.nlm.nih.gov/pubmed/19156127 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/msb.2008.72 |
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