Activation of the mitochondrial unfolded protein response promotes longevity and dopamine neuron survival in Parkinson’s disease models

While the pathogenesis of Parkinson’s disease (PD) is incompletely understood, mitochondrial dysfunction is thought to play a crucial role in disease pathogenesis. Here, we examined the relationship between mitochondrial function and dopamine neuron dysfunction and death using C. elegans mutants for...

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Vydáno v:Sci Rep
Hlavní autoři: Cooper, Jason F., Machiela, Emily, Dues, Dylan J., Spielbauer, Katie K., Senchuk, Megan M., Van Raamsdonk, Jeremy M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5703891/
https://ncbi.nlm.nih.gov/pubmed/29180793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-16637-2
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