Mitochondrial unfolded protein response transcription factor ATFS-1 promotes longevity in a long-lived mitochondrial mutant through activation of stress response pathways

Abstract Background The mitochondrial unfolded protein response (mitoUPR) is a stress response pathway activated by disruption of proteostasis in the mitochondria. This pathway has been proposed to influence lifespan, with studies suggesting that mitoUPR activation has complex effects on longevity....

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Main Authors: Ziyun Wu, Megan M. Senchuk, Dylan J. Dues, Benjamin K. Johnson, Jason F. Cooper, Leira Lew, Emily Machiela, Claire E. Schaar, Heather DeJonge, T. Keith Blackwell, Jeremy M. Van Raamsdonk
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2018-12-01
Colecção:BMC Biology
Assuntos:
Aging
Lifespan
Mitochondria
C. elegans
Mitochondrial unfolded protein response
ATFS-1
Acesso em linha:http://link.springer.com/article/10.1186/s12915-018-0615-3
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