Mitochondrial unfolded protein response transcription factor ATFS-1 promotes longevity in a long-lived mitochondrial mutant through activation of stress response pathways

BACKGROUND: The mitochondrial unfolded protein response (mitoUPR) is a stress response pathway activated by disruption of proteostasis in the mitochondria. This pathway has been proposed to influence lifespan, with studies suggesting that mitoUPR activation has complex effects on longevity. RESULTS:...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:BMC Biol
Κύριοι συγγραφείς: Wu, Ziyun, Senchuk, Megan M., Dues, Dylan J., Johnson, Benjamin K., Cooper, Jason F., Lew, Leira, Machiela, Emily, Schaar, Claire E., DeJonge, Heather, Blackwell, T. Keith, Van Raamsdonk, Jeremy M.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: BioMed Central 2018
Θέματα:
Research Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6298126/
https://ncbi.nlm.nih.gov/pubmed/30563508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12915-018-0615-3
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